PROGRAM
Wednesday, 3 September
14:00–22:00 Registration and room assignments (Swope Center, 1st Floor)
17:30–19:00 Dinner (Swope Center, Hall, 2nd Floor)
19:15–19:30 Opening remarks (Clapp Auditorium, Lillie Building)
Anne Carlson and Zhaozhu Qiu, Meeting Organizers
Baron Chanda, President, Society of General Physiologists
19:30–20:45 Friends of Physiology Keynote Lecture
Jue Chen (Rockefeller University)
Molecular mechanisms underpinning cystic fibrosis pathology and pharmacology
21:00–23:00 Travel Awards Presentation and Mixer (Swope Center, Meigs Room)
Thursday, 4 September
07:30–08:30 Breakfast (Swope Center, Dining Room)
All Sessions (1–3) will be held in the Clapp Auditorium, Lillie Building. Poster Session A will be held in Swope, 2nd Fl.
08:30–10:15 Session 1: Chloride Channels and Transporters in the Neurological Disorders
Jia Zhou (University of California San Diego) Resolving native GABAA receptor structures from the human brain
Michael Pusch (Istituto di Biofisica, Genova, Italia) Endolysosomal chloride/proton antiporters in human diseases: a
biophysical perspective
Tingting Yang (Columbia University) Bestrophins: structure, function and diseases
Short Talk 1 (15 min)
10:15–10:45 Break
10:45–12:30 Session 2: Structural Mechanisms of CLC Chloride/Proton Exchangers
Alessio Accardi (Cornell University) Structural basis of gating and coupling in a CLC-type H+/ Cl− transporter
Merritt Maduke (Stanford University) Biophysical and physiological mechanisms of the voltage-gated chloride channel CLC-2
Short talk 2 (15 min)
Flash Poster Preview (10 posters, 3 minutes each)
12:30–15:30 Lunch and Free Time
15:30–16:30 Roundtable Discussion on Promoting Equity in Science: Building and Supporting Inclusive Research Teams
(Meigs Room, Swope)
16:30–18:00 Poster Session A (Swope 2nd Floor)
18:00–19:00 Dinner (Swope Center, Dining Hall)
19:20–21:05 Session 3: Drug Discovery and Regulation of CFTR
This session is generously supported by Vertex Pharmaceuticals as a Gold Sponsor
Fred Van Goor (Vertex)
Liudmila Cebotaru (Johns Hopkins University) Role of CFTR in PKD
László Csanády (Semmelweis University) Two modes of regulation of the CFTR anion channel by protein kinase A
Short talk 3 (15 min)
21:15–23:15 Evening at the Captain Kidd (77 Water Street, Woods Hole)
Friday, 5 September
07:00–08:00 Breakfast (Swope Center, Dining Hall)
All Sessions (4–6) will be held in the Clapp Auditorium, Lillie Building. The Panel Discussion and Poster Session B will be held in Swope, 2nd Fl.
08:30–10:15 Session 4: Chloride Channels and Transporters in the Cardiovascular Systems
Jonathan Jaggar (University of Tennessee) TMEM16A channels in endothelial cells
Christine Klemens (University of South Florida) Chloride and Calcium: The Role of ClC-6 in Vascular Contractility and
Remodeling During Hypertension
Rajan Sah (Washington University School of Medicine) SWELL anion channels LRRCing in platelets
Short talk 4 (15 min)
10:15–10:45 Break
10:45–12:30 Session 5: Diversity of Chloride Channels and Transporters
Olga Boudker (Cornell University) Conformational dynamics of excitatory amino acid transporters with a dual role
as chloride channels
Thomas Jentsch (Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin) Novel insight into endosomal
chloride homeostasis
Randy Stockbridge (University of Michigan) Fluoride transport across domains of life
Short talk 5 (15 min)
12:30–15:30 Lunch and Free Time
15:30–16:30 Career Development Panel Discussion: Effective Science Communication
16:30–18:00 Poster Session B (Swope 2nd Floor)
18:00–19:00 Dinner (Swope Center, Dining Hall)
19:20–21:05 Session 6: New Tools for Studying Chloride Channels and Transporters
This session is generously supported by the Journal of General Physiology as a Silver Sponsor
Henry Colecraft (Columbia University) Exploiting the ubiquitin system to regulate ion channel expression for therapy
Sheel Dodani (University of Texas at Dallas) Illuminating chloride in biology
Rod MacKinnon (Rockefeller University) Higher order transient structures and the principle of dynamic connectivity in
membrane signaling
Short talk 6 (15 min)
21:15–23:15 Evening at the Captain Kidd (77 Water Street, Woods Hole)
Saturday, 6 September
07:00–08:00 Breakfast (Swope Center, Dining Hall)
08:30–9:45 Session 7: Emerging Fields in Chloride Biology
Cary Boyd-Shiwarski (University of Pittsburgh School of Medicine) A new phase for WNK kinases as regulators of
cation-chloride cotransporters
Axel Concepcion (University of Chicago) Chloride channels and transporters in T lymphocyte function
Short talk 7 (15 min)
9:45–10:15 SGP Excelsior Award Lecture
2025 Excelsior Awardee
10:15–10:45 Break
10:45–12:30 Session 8: Structure and Function of Chloride Channels
Michael Grabe (University of California San Francisco) The heads and tails of lipid interactions with TMEM16s
Raimund Dutzler (Universität Zürich) Volume regulated anion channels: from mechanisms to disease
Short talk 8 (15 min)
Short talk 9 (15 min)
Short talk 10 (15 min)
12:30–12:35 Group Photo
12:35–16:45 Lunch and Free Time
13:15–14:45 1st Boat Trip (Optional) Meet in Swope Lobby at 1:00 pm sharp
14:45–16:15 2nd Boat Trip (Optional) Meet in Swope Lobby at 2:30 pm sharp
16:45–18:30 Session 9: Regulation of Chloride Channels and Transporters
Joseph Mindell (National Institutes of Health)
Jorge Arreola (Universidad Autónoma de San Luis Potosí) Regulation of the calcium-activated chloride channel TMEM16A
Short talk 11 (15 min)
Short talk 12 (15 min)
Short talk 13 (15 min)
18:30-20:00 Lobster Banquet and Poster Awards Presentation (Swope Terrace)
20:00-22:00 Closing Mixer (Swope Terrace)
Sunday, 7 September
07:00–08:00 Breakfast (Swope Center, Dining Hall)
10:00 Checkout Deadline