Download the program booklet: sgp_2025_annual_meeting_program.pdf
PROGRAM
Wednesday, 3 September
2:00 pm–10:00 pm Registration and room assignments (Swope Center, 1st Floor)
5:30 pm–7:00 pm Dinner (Swope Center, Hall, 2nd Floor)
7:15 pm–7:30 pm Opening remarks (Clapp Auditorium, Lillie Building)
Anne Carlson and Zhaozhu Qiu, Meeting Organizers
Baron Chanda, President, Society of General Physiologists
Gregory Malar, Executive Director, Society of General Physiologists
7:30 pm–8:45 pm Friends of Physiology Keynote Lecture
Jue Chen (Rockefeller University)
Molecular mechanisms underpinning cystic fibrosis pathology and pharmacology
9:00 pm–11:00 pm Travel Awards Presentation and Mixer (Swope Center, Meigs Room)
Thursday, 4 September
7:30 am–8:30 am Breakfast (Swope Center, Dining Room)
All Sessions (1–3) will be held in the Clapp Auditorium, Lillie Building. Poster Session A will be held in Swope, 2nd Fl.
8:30 am–10:15 am Session 1: Chloride Channels and Transporters in the Neurological Disorders
Chair: Olga Boudker (Weill Cornell Medicine)
8:30 am–9:00 am Jia Zhou (University of California San Diego)
Resolving native GABAA receptor structures from the human brain
9:00 am–9:30 am Michael Pusch (Istituto di Biofisica, Genova, Italia)
Endolysosomal chloride/proton antiporters in human diseases: a biophysical perspective
9:30 am-10:00 am Tingting Yang (Columbia University)
Bestrophins: structure, function and diseases
10:00 am-10:15 am Raul Estevez (University of Barcelona)
Identification of a novel GPCR interacting with LRRC8A and modulating VRAC function
10:15 am–10:45 am Break
10:45 am–12:30 am Session 2: Structural Mechanisms of CLC Chloride/Proton Exchangers
Chair: Chris Miller (Brandeis University)
10:45 am-11:15 am Merritt Maduke (Stanford University)
Biophysical and physiological mechanisms of the voltage-gated chloride channel CLC-2
11:15 am-11:30 am Shwetha Srinivasan (Stanford University) (34 A-Thu)
A structural view of gating and conductance in CLC-0
11:30 am-12:00 pm Joseph Mindell (National Institutes of Health)
Mechanism of ClC-7 inhibition by lysosomal phosphoinositides
12:00 pm-12:30 pm Flash Poster Previews: abstract numbers/poster session in parentheses
Olivér Závoti (13 B-Fri) (Semmelweis University) Molecular and pharmacological evaluation of rare, cystic fibrosis causing missense mutations of the CFTR channel
James Charlick (35 B-Fri) (University of Bristol) Acute co-treatment with elexacaftor and ivacaftor restores wild-type-like activity to single elexacaftor-tezacaftor-ivacaftor-rescued F508del-CFTR channels
Jyosthna Lunavath (45 B Fri) (University College London) High-content dual-fluorescence assay to quantify CFTR biogenesis and chloride vs. bicarbonate ion-channel function
Elena Lehmann (16 A-Thu) (University of Zurich) Insight into activation and selectivity of volume regulated heteromeric LRRC8A/D channels
Toshiki Yamada (46 A-Thu) (Vanderbilt University) A conserved mechanism of LRRC8 channel inhibition by three distinct drugs
Paolo Zuccolini (37 B-Fri) (NIH/NINDS) New disease-inducing mutations of the CLC-7 lysosomal transporter in mutant homodimers and heterodimers
Jason Rengo (60 A-Thu) (UVM) G-protein coupled receptors regulate mouse urinary bladder phasic smooth muscle contractions, potentially through potassium channels and calcium-activated chloride channels
Veronica Loyo Celis (41 B-Fri) (Ohio State University) Molecular determinants of pH sensing in the chloride intracellular channel 3 (CLIC3)
Chia-Yu Kang (28 A-Thu) (University of Michigan) Structural determination and export mechanism of the eukaryotic fluoride exporter (FEX) proteins
12:30 pm-4:30 pm Lunch (12:30 pm-1:30 pm, Swope Center) and Free Time
3:30 pm-4:30 pm Roundtable Discussion: Careers in Industry: Opportunities, Challenges, and Insights (Meigs Room, Swope)
Panelists: Federico Amodeo (Nanion Technologies), Fred Van Goor (Vertex Pharmaceuticals), and
Pietro Scaduto (Sophion Bioscience)
4:30 pm–6:00 pm Poster Session A and visits with exhibitors (Swope 2nd Floor). Even numbered abstracts.
6:00 pm–7:00 pm Dinner (Swope Center, Dining Hall)
7:15 pm–9:00 pm Session 3: Drug Discovery and Regulation of CFTR
Chair: Bill Guggino (Johns Hopkins University)
Generously supported by Vertex Pharmaceuticals as a Gold Sponsor
7:15 pm-7:45 pm Fred Van Goor (Vertex)
Discovery of CFTR modulators for the treatment of cystic fibrosis
7:45 pm-8:15 pm László Csanády (Semmelweis University)
Two modes of regulation of the CFTR anion channel by protein kinase A
8:15 pm-8:30 pm Paramita Sarkar (NIH/NIDCR) (49 B-Fri)
An ER/PM junctional phosphatidylserine specified by E-Syt3 mediates signaling by the cAMP pathway to regulate CFTR
8:30 pm-9:00 pm Liudmila Cebotaru (Johns Hopkins University) Role of CFTR in PKD
9:00 pm–11:00 pm Evening at the Captain Kidd (77 Water Street, Woods Hole)
Friday, 5 September
7:30 am–8:30 am Breakfast (Swope Center, Dining Hall)
All Sessions (4–6) will be held in the Clapp Auditorium, Lillie Building. The Panel Discussion and Poster Session B will be held in Swope, 2nd Fl.
8:30 am-10:15 am Session 4: Chloride Channels and Transporters in the Cardiovascular Systems
Generously supported by Sophion Bioscience as a Silver Sponsor
Chair: Tessa Garrud (University of Tennessee Health Science Center)
8:30 am-9:00 am Jonathan Jaggar (University of Tennessee)
TMEM16A channels in endothelial cells
9:00 am-9:15 am Tom Longden (University of Maryland Baltimore) 53 B-Fri
TMEM16A channels in capillary thin-strand pericytes control brain blood flow
9:15 am-9:45 am Christine Klemens (University of South Florida)
Chloride and calcium: The role of ClC-6 in vascular contractility and remodeling during hypertension
9:45 am-10:15 am Rajan Sah (Washington University School of Medicine)
SWELL anion channels LRRCing in platelets
10:15 am–10:45 am Break
10:45 am–12:30 pm Session 5: Diversity of Chloride Channels and Transporters
Chair: Venkata Shiva Mandala (Rockefeller University)
10:45 am-11:15 am Qianyi Wu (Weill Cornell Medicine)
Conformational dynamics of excitatory amino acid transporters with a dual role as chloride channels
11:15 am-11:45 am Thomas Jentsch (Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin)
Novel insight into endosomal chloride homeostasis
11:45 am-12:00 pm Tatsuya Hagino (Johns Hopkins University) 25 B-Fri
Structural analysis of volume-regulated anion channel SWELL1 in complex with a novel auxiliary subunit PSA
12:00 pm-12:30 pm Randy Stockbridge (University of Michigan)
Fluoride transport across domains of life
12:30 pm-12:40 pm Group Photo (Lillie Building Front Steps)
12:40 pm-3:30 pm Lunch
4:30 pm-6:00 pm Poster Session B and visits with exhibitors (2nd Fl, Swope Center)
6:00 pm-7:00 pm Dinner (Dining Hall, Swope Center)
7:15 pm-8:45 pm Session 6: New Tools for Studying Chloride Channels and Transporters
This session is generously supported by the Journal of General Physiology as a Silver Sponsor
Chair: Jasmine Tutol (University of Texas Dallas)
7:15 pm-7:45 pm Sheel Dodani (University of Texas at Dallas)
Illuminating chloride in biology
7:45 pm-8:00 pm Kaho Leung (University of South Carolina) 29 B-Fri
Quantitative subcellular imaging tools for investigating chloride pathophysiology
8:00 pm-8:30 pm Rod MacKinnon (Rockefeller University) Higher order transient structures and the principle of dynamic connectivity
in membrane signaling
8:30 pm-8:45pm Olive Burata (Nanion)
SURFE²R N1: Direct electrophysiology for chloride transport
9:00 pm-11:00 pm Evening at the Captain Kidd (77 Water Street, Woods Hole)
Saturday, 6 September
7:30 am–8:30 am Breakfast (Swope Center, Dining Hall)
8:30 am-10:15 am Session 7: Emerging Fields in Chloride Biology
Chair: Eric Sefah (NIH)
8:30 am-9:00 am Cary Boyd-Shiwarski (University of Pittsburgh)
A new phase for WNK kinases as regulators of cation-chloride cotnansporters
9:00 am-9:30 am Axel Concepcion (University of Chicago)
Chloride channels and transporters in T lymphocyte function
9:30 am-10:00 am Fan Yang (Zhejiang University)
Discovery and structural basis of endogenous and exogenous inhibitors of the proton-activated-chloride channel
10:00 am-10:15 am Stephen Long (Sloan Kettering Institute) 7 B-Fri
The pentameric chloride channel BEST1 is activated by extracellular GABA
10:15 am-10:45 am Break
10:45 am–12:15 pm Session 8: Structure and Function of Chloride Channels
Chair: Chris Peters (University of Illinois Chicago)
10:45 am-11:15 am Alessio Accardi (Cornell University)
Structural basis of gating and coupling in a CLC-type H+/ Cl− transporter
11:15 am-11:30 am Crystal Lara-Santos (University of Pittsburgh) 21 B-Fri
Delineating the structural features of polyunsaturated fatty acids required to inhibit the calcium-activated chloride
channel TMEM16A
11:30 am-12:00 pm Michael Grabe (University of California San Francisco)
The heads and tails of lipid interactions with TMEM16s
12:00 am-12:15 pm Sangyun Lee (Weill Cornell Medicine) 38 A-Thu
Structural basis of uncoupling in a CLC transporter
12:30 pm-4:45 pm Lunch (12:30 pm to 1:30 pm) and Free Time
1:30 pm-3:00 pm 1st Boat Trip (Optional) Meet in the Swope Lobby at 1:15 pm sharp
3:00 pm-4:30 pm 2nd Boat Trip (Optional) Meet in the Swope Lobby at 2:45 pm sharp
4:45 pm-6:30 pm Session 9: Regulation of Chloride Channels and Transporters
Chair: Elena Lehmann (Universität Zürich)
4:45 pm-5:15 pm Raimund Dutzler (Universität Zürich)
Volume regulated anion channels: from mechanisms to disease
5:15 pm-5:30 pm Tobias StauberTobias Stauber (MSH Medical School Hamburg)
The intracellular subdomain of the VRAC/LRRC8 channel subunit LRRC8A is a hotspot of channel activation
5:30 pm-6:00 pm Jorge Arreola (Universidad Autónoma de San Luis Potosí)
Regulation of the calcium-activated chloride channel TMEM16A
6:00 pm-6:15 pm Hyun-Ho Lim (Korea Brain Research Institute)
Probing coordinated gating of inner and outer gates in a CLC antiporte through mutational and structural analyses
6:15 pm-6:30 pm Francisco J. Alvarez-Leefmans (Wright State University)
NKCC1 flux reversal measured in single epithelial cells using fluorescent imaging microscopy
6:30 pm-8:00 pm Lobster Banquet and Poster Award Presentations (Swope Terrace)
8:00 pm -10:00 pm Closing Mixer (Swope Terrace)
Sunday, 7 September
7:30 am-8:30 am Breakfast (Dining Hall, Swope Center)
10:00 am Swope Checkout Deadline
2:00 pm–10:00 pm Registration and room assignments (Swope Center, 1st Floor)
5:30 pm–7:00 pm Dinner (Swope Center, Hall, 2nd Floor)
7:15 pm–7:30 pm Opening remarks (Clapp Auditorium, Lillie Building)
Anne Carlson and Zhaozhu Qiu, Meeting Organizers
Baron Chanda, President, Society of General Physiologists
Gregory Malar, Executive Director, Society of General Physiologists
7:30 pm–8:45 pm Friends of Physiology Keynote Lecture
Jue Chen (Rockefeller University)
Molecular mechanisms underpinning cystic fibrosis pathology and pharmacology
9:00 pm–11:00 pm Travel Awards Presentation and Mixer (Swope Center, Meigs Room)
Thursday, 4 September
7:30 am–8:30 am Breakfast (Swope Center, Dining Room)
All Sessions (1–3) will be held in the Clapp Auditorium, Lillie Building. Poster Session A will be held in Swope, 2nd Fl.
8:30 am–10:15 am Session 1: Chloride Channels and Transporters in the Neurological Disorders
Chair: Olga Boudker (Weill Cornell Medicine)
8:30 am–9:00 am Jia Zhou (University of California San Diego)
Resolving native GABAA receptor structures from the human brain
9:00 am–9:30 am Michael Pusch (Istituto di Biofisica, Genova, Italia)
Endolysosomal chloride/proton antiporters in human diseases: a biophysical perspective
9:30 am-10:00 am Tingting Yang (Columbia University)
Bestrophins: structure, function and diseases
10:00 am-10:15 am Raul Estevez (University of Barcelona)
Identification of a novel GPCR interacting with LRRC8A and modulating VRAC function
10:15 am–10:45 am Break
10:45 am–12:30 am Session 2: Structural Mechanisms of CLC Chloride/Proton Exchangers
Chair: Chris Miller (Brandeis University)
10:45 am-11:15 am Merritt Maduke (Stanford University)
Biophysical and physiological mechanisms of the voltage-gated chloride channel CLC-2
11:15 am-11:30 am Shwetha Srinivasan (Stanford University) (34 A-Thu)
A structural view of gating and conductance in CLC-0
11:30 am-12:00 pm Joseph Mindell (National Institutes of Health)
Mechanism of ClC-7 inhibition by lysosomal phosphoinositides
12:00 pm-12:30 pm Flash Poster Previews: abstract numbers/poster session in parentheses
Olivér Závoti (13 B-Fri) (Semmelweis University) Molecular and pharmacological evaluation of rare, cystic fibrosis causing missense mutations of the CFTR channel
James Charlick (35 B-Fri) (University of Bristol) Acute co-treatment with elexacaftor and ivacaftor restores wild-type-like activity to single elexacaftor-tezacaftor-ivacaftor-rescued F508del-CFTR channels
Jyosthna Lunavath (45 B Fri) (University College London) High-content dual-fluorescence assay to quantify CFTR biogenesis and chloride vs. bicarbonate ion-channel function
Elena Lehmann (16 A-Thu) (University of Zurich) Insight into activation and selectivity of volume regulated heteromeric LRRC8A/D channels
Toshiki Yamada (46 A-Thu) (Vanderbilt University) A conserved mechanism of LRRC8 channel inhibition by three distinct drugs
Paolo Zuccolini (37 B-Fri) (NIH/NINDS) New disease-inducing mutations of the CLC-7 lysosomal transporter in mutant homodimers and heterodimers
Jason Rengo (60 A-Thu) (UVM) G-protein coupled receptors regulate mouse urinary bladder phasic smooth muscle contractions, potentially through potassium channels and calcium-activated chloride channels
Veronica Loyo Celis (41 B-Fri) (Ohio State University) Molecular determinants of pH sensing in the chloride intracellular channel 3 (CLIC3)
Chia-Yu Kang (28 A-Thu) (University of Michigan) Structural determination and export mechanism of the eukaryotic fluoride exporter (FEX) proteins
12:30 pm-4:30 pm Lunch (12:30 pm-1:30 pm, Swope Center) and Free Time
3:30 pm-4:30 pm Roundtable Discussion: Careers in Industry: Opportunities, Challenges, and Insights (Meigs Room, Swope)
Panelists: Federico Amodeo (Nanion Technologies), Fred Van Goor (Vertex Pharmaceuticals), and
Pietro Scaduto (Sophion Bioscience)
4:30 pm–6:00 pm Poster Session A and visits with exhibitors (Swope 2nd Floor). Even numbered abstracts.
6:00 pm–7:00 pm Dinner (Swope Center, Dining Hall)
7:15 pm–9:00 pm Session 3: Drug Discovery and Regulation of CFTR
Chair: Bill Guggino (Johns Hopkins University)
Generously supported by Vertex Pharmaceuticals as a Gold Sponsor
7:15 pm-7:45 pm Fred Van Goor (Vertex)
Discovery of CFTR modulators for the treatment of cystic fibrosis
7:45 pm-8:15 pm László Csanády (Semmelweis University)
Two modes of regulation of the CFTR anion channel by protein kinase A
8:15 pm-8:30 pm Paramita Sarkar (NIH/NIDCR) (49 B-Fri)
An ER/PM junctional phosphatidylserine specified by E-Syt3 mediates signaling by the cAMP pathway to regulate CFTR
8:30 pm-9:00 pm Liudmila Cebotaru (Johns Hopkins University) Role of CFTR in PKD
9:00 pm–11:00 pm Evening at the Captain Kidd (77 Water Street, Woods Hole)
Friday, 5 September
7:30 am–8:30 am Breakfast (Swope Center, Dining Hall)
All Sessions (4–6) will be held in the Clapp Auditorium, Lillie Building. The Panel Discussion and Poster Session B will be held in Swope, 2nd Fl.
8:30 am-10:15 am Session 4: Chloride Channels and Transporters in the Cardiovascular Systems
Generously supported by Sophion Bioscience as a Silver Sponsor
Chair: Tessa Garrud (University of Tennessee Health Science Center)
8:30 am-9:00 am Jonathan Jaggar (University of Tennessee)
TMEM16A channels in endothelial cells
9:00 am-9:15 am Tom Longden (University of Maryland Baltimore) 53 B-Fri
TMEM16A channels in capillary thin-strand pericytes control brain blood flow
9:15 am-9:45 am Christine Klemens (University of South Florida)
Chloride and calcium: The role of ClC-6 in vascular contractility and remodeling during hypertension
9:45 am-10:15 am Rajan Sah (Washington University School of Medicine)
SWELL anion channels LRRCing in platelets
10:15 am–10:45 am Break
10:45 am–12:30 pm Session 5: Diversity of Chloride Channels and Transporters
Chair: Venkata Shiva Mandala (Rockefeller University)
10:45 am-11:15 am Qianyi Wu (Weill Cornell Medicine)
Conformational dynamics of excitatory amino acid transporters with a dual role as chloride channels
11:15 am-11:45 am Thomas Jentsch (Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin)
Novel insight into endosomal chloride homeostasis
11:45 am-12:00 pm Tatsuya Hagino (Johns Hopkins University) 25 B-Fri
Structural analysis of volume-regulated anion channel SWELL1 in complex with a novel auxiliary subunit PSA
12:00 pm-12:30 pm Randy Stockbridge (University of Michigan)
Fluoride transport across domains of life
12:30 pm-12:40 pm Group Photo (Lillie Building Front Steps)
12:40 pm-3:30 pm Lunch
4:30 pm-6:00 pm Poster Session B and visits with exhibitors (2nd Fl, Swope Center)
6:00 pm-7:00 pm Dinner (Dining Hall, Swope Center)
7:15 pm-8:45 pm Session 6: New Tools for Studying Chloride Channels and Transporters
This session is generously supported by the Journal of General Physiology as a Silver Sponsor
Chair: Jasmine Tutol (University of Texas Dallas)
7:15 pm-7:45 pm Sheel Dodani (University of Texas at Dallas)
Illuminating chloride in biology
7:45 pm-8:00 pm Kaho Leung (University of South Carolina) 29 B-Fri
Quantitative subcellular imaging tools for investigating chloride pathophysiology
8:00 pm-8:30 pm Rod MacKinnon (Rockefeller University) Higher order transient structures and the principle of dynamic connectivity
in membrane signaling
8:30 pm-8:45pm Olive Burata (Nanion)
SURFE²R N1: Direct electrophysiology for chloride transport
9:00 pm-11:00 pm Evening at the Captain Kidd (77 Water Street, Woods Hole)
Saturday, 6 September
7:30 am–8:30 am Breakfast (Swope Center, Dining Hall)
8:30 am-10:15 am Session 7: Emerging Fields in Chloride Biology
Chair: Eric Sefah (NIH)
8:30 am-9:00 am Cary Boyd-Shiwarski (University of Pittsburgh)
A new phase for WNK kinases as regulators of cation-chloride cotnansporters
9:00 am-9:30 am Axel Concepcion (University of Chicago)
Chloride channels and transporters in T lymphocyte function
9:30 am-10:00 am Fan Yang (Zhejiang University)
Discovery and structural basis of endogenous and exogenous inhibitors of the proton-activated-chloride channel
10:00 am-10:15 am Stephen Long (Sloan Kettering Institute) 7 B-Fri
The pentameric chloride channel BEST1 is activated by extracellular GABA
10:15 am-10:45 am Break
10:45 am–12:15 pm Session 8: Structure and Function of Chloride Channels
Chair: Chris Peters (University of Illinois Chicago)
10:45 am-11:15 am Alessio Accardi (Cornell University)
Structural basis of gating and coupling in a CLC-type H+/ Cl− transporter
11:15 am-11:30 am Crystal Lara-Santos (University of Pittsburgh) 21 B-Fri
Delineating the structural features of polyunsaturated fatty acids required to inhibit the calcium-activated chloride
channel TMEM16A
11:30 am-12:00 pm Michael Grabe (University of California San Francisco)
The heads and tails of lipid interactions with TMEM16s
12:00 am-12:15 pm Sangyun Lee (Weill Cornell Medicine) 38 A-Thu
Structural basis of uncoupling in a CLC transporter
12:30 pm-4:45 pm Lunch (12:30 pm to 1:30 pm) and Free Time
1:30 pm-3:00 pm 1st Boat Trip (Optional) Meet in the Swope Lobby at 1:15 pm sharp
3:00 pm-4:30 pm 2nd Boat Trip (Optional) Meet in the Swope Lobby at 2:45 pm sharp
4:45 pm-6:30 pm Session 9: Regulation of Chloride Channels and Transporters
Chair: Elena Lehmann (Universität Zürich)
4:45 pm-5:15 pm Raimund Dutzler (Universität Zürich)
Volume regulated anion channels: from mechanisms to disease
5:15 pm-5:30 pm Tobias StauberTobias Stauber (MSH Medical School Hamburg)
The intracellular subdomain of the VRAC/LRRC8 channel subunit LRRC8A is a hotspot of channel activation
5:30 pm-6:00 pm Jorge Arreola (Universidad Autónoma de San Luis Potosí)
Regulation of the calcium-activated chloride channel TMEM16A
6:00 pm-6:15 pm Hyun-Ho Lim (Korea Brain Research Institute)
Probing coordinated gating of inner and outer gates in a CLC antiporte through mutational and structural analyses
6:15 pm-6:30 pm Francisco J. Alvarez-Leefmans (Wright State University)
NKCC1 flux reversal measured in single epithelial cells using fluorescent imaging microscopy
6:30 pm-8:00 pm Lobster Banquet and Poster Award Presentations (Swope Terrace)
8:00 pm -10:00 pm Closing Mixer (Swope Terrace)
Sunday, 7 September
7:30 am-8:30 am Breakfast (Dining Hall, Swope Center)
10:00 am Swope Checkout Deadline